What is Actonel? Actonel is in a congregation of medicines called bisphosphonates (bis FOS fo nayts). It alters the pattern of bone crystallization and crack-up in the body. It slows bone impoverishment while increasing bone mass, which may prevent bone fractures. Actonel is utilized to manipulation of or prevent osteoporosis in men and women. Actonel is also inured to to nurse Paget's illness of bone. Actonel may also be utilized for other purposes not listed.